Combination of synthetic peptides derived from bone morphogenetic proteins and biomaterials for medical applications

Authors

  • H. Senta,

    1. Cell-Biomaterial Biohybrid Systems, Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada
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  • E. Bergeron,

    1. Cell-Biomaterial Biohybrid Systems, Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada
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  • O. Drevelle,

    1. Cell-Biomaterial Biohybrid Systems, Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada
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  • H. Park,

    1. Cell-Biomaterial Biohybrid Systems, Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada
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  • N. Faucheux

    Corresponding author
    1. Cell-Biomaterial Biohybrid Systems, Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada
    • Cell-Biomaterial Biohybrid Systems, Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada.
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Abstract

A critical-size bone defect cannot repair itself. These defects are presently filled by bone grafts or with biomaterials that mimic bone properties. The activity of bone cells is modulated by cytokines like the bone morphogenetic proteins (BMPs). This review described the peptides derived from BMPs or extracellular matrix proteins which can be immobilised on biomaterials to increase their action on bone cells and promote healing. However, the development of such materials requires peptides that can act in synergy. This requires the use of model surfaces to better understand how cells perceive biomaterials.

Abstract

La réparation des pertes osseuses ne se fait pas au delà d'une taille critique. Les greffes ou les biomatériaux mimant les propriétés de ce tissu sont actuellement utilisés pour combler ces pertes. Les cellules osseuses sont régulées par de nombreuses cytokines, telles les protéines morphogénétiques osseuses (BMPs). Cette revue de la littérature décrit l'immobilisation sur les biomatériaux de peptides dérivés des BMPs ou des protéines de la matrice extracellulaire qui permet leur action sélective pour favoriser une meilleure guérison. Cependant, le développement de ces matériaux implique non seulement la sélection de peptides agissant en synergie, mais aussi une meilleure connaissance des interactions cellules-biomatériaux en utilisant des surfaces modèles.

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