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In-line near infrared spectroscopy monitoring of pharmaceutical powder moisture in a fluidised bed dryer: An efficient methodology for chemometric model development

Authors

  • Anne-Marie Demers,

    1. Université de Sherbrooke, Department of Chemical and Biotechnological Engineering, Pfizer Industrial Research Chair on PAT in Pharmaceutical Engineering, Sherbrooke, Quebec, Canada
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  • Ryan Gosselin,

    1. Université de Sherbrooke, Department of Chemical and Biotechnological Engineering, Pfizer Industrial Research Chair on PAT in Pharmaceutical Engineering, Sherbrooke, Quebec, Canada
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  • Jean-Sébastien Simard,

    1. Process Analytical Science Group, Global Manufacturing Services, Pfizer, Montreal, Quebec, Canada
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  • Nicolas Abatzoglou

    Corresponding author
    1. Université de Sherbrooke, Department of Chemical and Biotechnological Engineering, Pfizer Industrial Research Chair on PAT in Pharmaceutical Engineering, Sherbrooke, Quebec, Canada
    • Université de Sherbrooke, Department of Chemical and Biotechnological Engineering, Pfizer Industrial Research Chair on PAT in Pharmaceutical Engineering, Sherbrooke, Quebec, Canada
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Abstract

This work proposes a novel chemometric methodology for in-line near infrared spectroscopy (NIRS) monitoring of pharmaceutical powder moisture in a fluidised-bed dryer. The collected spectra are analysed by multivariate chemometrics involving the preparation of numerous laboratory samples. A different methodology, using only plant samples, was tested in real-time. A specially designed probe tip, allowing for robust in-situ spectral acquisition, was designed. The results prove that NIRS can be as efficient as traditional quality analyses, e.g. loss-on-drying, in measuring powder moisture content in a fluidised bed dryer with a calibration model based only on plant samples. © 2011 Canadian Society for Chemical Engineering

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