Study of pressure fluctuations in an internal loop airlift bioreactor

Authors

  • Lijia Luo,

    1. Department of Automation, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China
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  • Ying Yan,

    1. Department of Automation, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China
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  • Yuanyuan Xu,

    1. Department of Automation, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China
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  • Ping Xie,

    1. Hebei Welcome Pharmaceutical Co. Ltd., North China Pharmaceutical Company, Shijiazhuang 050031, China
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  • Junwei Sun,

    1. Hebei Welcome Pharmaceutical Co. Ltd., North China Pharmaceutical Company, Shijiazhuang 050031, China
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  • Wei Guo,

    1. Hebei Welcome Pharmaceutical Co. Ltd., North China Pharmaceutical Company, Shijiazhuang 050031, China
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  • Jingqi Yuan

    Corresponding author
    1. Department of Automation, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China
    • Department of Automation, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China.
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Abstract

The origin and coupling of pressure fluctuations in an internal loop airlift bioreactor are investigated. The pressure fluctuations in the reactor are divided into two categories: global pressure fluctuations and local pressure fluctuations. It is found that the coupling between global pressure fluctuations and local pressure fluctuations mainly focuses in the frequency region between 10 and 30 Hz. Local pressure fluctuations in the reactor are strongly affected by pressure waves originating from the air-supply system, while pressure fluctuations caused by the bubble eruption at the liquid surface have less influence on local pressure fluctuations. Based on the coherence analysis, the pressure signal at a certain position in the reactor is decomposed into three different parts: coherent part, joint incoherent part and exclusive incoherent part. The energy ratios of these different parts are helpful to study the interaction among pressure fluctuations from different sources. Three flow regimes were identified from the evolution of the energy ratio of the joint incoherent part. © 2011 Canadian Society for Chemical Engineering

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