Get access

A feedback glucose control strategy for type II diabetes mellitus based on fuzzy logic

Authors

  • F. Ekram,

    1. Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall Vancouver, BC, Canada, V6T 1Z3
    Search for more papers by this author
  • L. Sun,

    1. Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall Vancouver, BC, Canada, V6T 1Z3
    Current affiliation:
    1. China University of Petroleum, Beijing, Box 260 Changping District, Beijing 102249, China.
    Search for more papers by this author
  • O. Vahidi,

    1. Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall Vancouver, BC, Canada, V6T 1Z3
    Search for more papers by this author
  • E. Kwok,

    Corresponding author
    1. Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall Vancouver, BC, Canada, V6T 1Z3
    • Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall Vancouver, BC, Canada, V6T 1Z3.
    Search for more papers by this author
  • R. B. Gopaluni

    1. Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall Vancouver, BC, Canada, V6T 1Z3
    Search for more papers by this author

Abstract

Most patients with severe Type II diabetes mellitus, characterised by both insulin resistance and β-cell failure, eventually require insulin therapy. According to the nonlinear dynamics of homeostasis of blood glucose, proportional-integral (PI) controller, modified by penalising the feedback error using a fuzzy inference system has been developed to maintain normoglycaemia in a simulated patient using a closed-loop insulin infusion pump. The simulation employs a compartment model proposed by Vahidi et al. [Vahidi et al., Biochem. Eng. J. 2011, 55(1), 7–16]. The results demonstrate that the fuzzy-based PI controller is superior to a conventional PI controller for the regulation of blood glucose by insulin infusion for Type II diabetic patients. © 2012 Canadian Society for Chemical Engineering

Ancillary