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Keywords:

  • Penicillium commune;
  • marine-derived fungus;
  • Gorgonian;
  • Muricella abnormalis;
  • aromatic polyketide;
  • antimicrobial activity

Abstract

Seven new aromatic polyketides, communols A–G (17), were isolated and identified from the fermentation broth of Penicillium commune 518, a marine-derived fungus associated with the Gorgonian, Muricella abnormalis. The new structures of 17 were determined by spectroscopic analysis and X-ray single crystal diffraction. Among them, communol D (4) was the first example of a naturally occurring aromatic polyketide with a sulfoxide group from marine fungi. Compounds 1, 6, and 7 all showed moderate antimicrobial activities against Escherichia coli and Enterobacter aerogenes with MIC values of 4.1/16.4, 6.4/25.8, and 23.8/23.8 µmol·L−1, respectively.