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Efficient Synthesis of β-Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst

  1. Zolfigol Mohammad Ali1,*,
  2. Khazaei Ardeshir1,*,
  3. Mokhlesi Mohammad1,
  4. Zare Abdolkarim2,
  5. Safaiee Maliheh3,
  6. Derakhshan-Panah Fatemeh1,
  7. Keypour Hassan1,
  8. Ali Dehghani-Firouzabadi Ahmad1,
  9. Merajoddin Maria2

Article first published online: 19 JAN 2012

DOI: 10.1002/cjoc.201180460

Issue

Chinese Journal of Chemistry

Chinese Journal of Chemistry

Volume 30, Issue 2, pages 345–352, February, 2012

Additional Information

How to Cite

Mohammad Ali, Z., Ardeshir, K., Mohammad, M., Abdolkarim, Z., Maliheh, S., Fatemeh, D.-P., Hassan, K., Ahmad, A. D.-F. and Maria, M. (2012), Efficient Synthesis of β-Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst. Chin. J. Chem., 30: 345–352. doi: 10.1002/cjoc.201180460

Author Information

  1. 1

    Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran

  2. 2

    Department of Chemistry, Payame Noor University, PO BOX 19395-3697 Tehran, Iran

  3. 3

    College of Science, Islamic Azad University, Hamedan Branch, Iran

*Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran

Publication History

  1. Issue published online: 15 FEB 2012
  2. Article first published online: 19 JAN 2012
  3. Manuscript Accepted: 31 AUG 2011
  4. Manuscript Received: 20 MAY 2011

Funded by

  • the Research Affairs Office of Bu-Ali Sina University. Grant Number: 32-1716

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Keywords:

  • β-acetamido ketone;
  • β-acetamido ester;
  • aluminum chloride;
  • enolizable ketone;
  • synthetic methods;
  • multicomponent reactions

Abstract

Aluminum chloride (AlCl3) efficiently catalyzes one-pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β-acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. Moreover, by this synthetic method, some novel β-acetamido ketones and esters (i.e. one complex structure) are prepared.

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