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Keywords:

  • highly functionalized heterocyclic compounds;
  • phosphorus ylides;
  • triphenylphosphine;
  • DFT;
  • dynamic 1H NMR

Abstract

The zwitterionic intermediate generated from the reaction of triphenylphosphine with electron deficient acetylenic compounds was trapped by various NH acids. The synthesis resulted in a new class of highly functionalized heterocyclic compounds. Some of the reactions produced E and Z isomers. And the stability and transformation of them were studied by dynamic 1H NMR and density functional theory (DFT) calculations.