DNA-Templated Silver Nanoclusters Formation at Gold Electrode Surface and Its Application to Hydrogen Peroxide Detection

Authors

  • Yuanyuan Xu,

    1. Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210093, China
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  • Yangyang Chen,

    1. Laboratory of Biosensing Technology, School of Life Science, Shanghai University, Shanghai 200444, China
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  • Nana Yang,

    1. Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210036, China
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  • Lizhou Sun,

    1. Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210036, China
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  • Genxi Li

    Corresponding author
    1. Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210093, China
    2. Laboratory of Biosensing Technology, School of Life Science, Shanghai University, Shanghai 200444, China
    • Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210093, China, Tel.: 0086-025-83593596; Fax: 0086-025-83592510
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Abstract

In this work, we have prepared Ag nanoclusters (Ag NCs) at gold electrode surface by using thiol-modified oligodeoxynucleotide consisting of eighteen cytosine deoxyribonucleotides (polyC18) as template and NaBH4 as reducing agent. Experimental results show that Ag nanoclusters (Ag NCs) can be formed around the template polyC18, while the formation can be characterized with electrochemical method. Further studies reveal that the fabricated Ag NCs may display high catalytic activity for the reduction of hydrogen peroxide (H2O2), which can be further used for the detection of H2O2.

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