Facile and Efficient Synthesis of (R)-4-(Benzyloxy)-3-methylbutanenitrile: Toward Developing a Versatile Chiral Building Block

Authors

  • Zijie Song,

    1. Laboratory of Resource Chemistry, Shanghai Normal University, 100 Guiling Road, Shanghai 200234, China
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  • Yong Shi,

    1. The Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
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  • Ronghua Jin,

    1. Laboratory of Resource Chemistry, Shanghai Normal University, 100 Guiling Road, Shanghai 200234, China
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  • Jingrong Lin,

    1. Laboratory of Resource Chemistry, Shanghai Normal University, 100 Guiling Road, Shanghai 200234, China
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  • Weisheng Tian

    Corresponding author
    1. The Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    • The Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
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Abstract

A practical synthesis of (R)-4-(benzyloxy)-3-methylbutanenitrile, a potential chiral building block, from the corresponding α-keto ester in high yield and large scale was presented.

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