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Keywords:

  • conjugate reduction;
  • aldol addition;
  • domino reaction;
  • copper hydride;
  • catalysis

Abstract

Intramolecular conjugate reduction-aldol addition reactions of β′-oxoalkyl α,β-unsaturated carboxylates were performed in the presence of copper catalysts generated in situ from copper salts, phosphine ligands and silanes. Moderate to good yields and high diastereoselectivities were obtained in 15 min to 3 h using bis[(2-diphenylphosphino)phenyl] ether as the ligand.