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Keywords:

  • protoporphyrin;
  • catalytic hydrogenation;
  • mesoporphyrin;
  • cobalt chloride;
  • sodium borohydride

Abstract

A convenient protocol has been developed for the hydrogenation of metallo-protoporphyrin IX dimethyl esters (MPPDMEs) to their mesoporphyrin analogues using CoCl2-NaBH4 reagent system. Metallo-porphyrin complexes were found to perform as self-catalysts in this procedure. This method provides several advantages such as safe and simple procedure, short reaction time, high yields and low cost.