Cucurbit[7]uril-Based Vesicles Formed by Self-assembly of Supramolecular Amphiphiles

Authors

  • Jiaxi Li,

    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
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  • Lipeng Zhou,

    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
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  • Quan Luo,

    Corresponding author
    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
    • Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China, Tel.: 0086-0431-85168452; Fax: 0086-0431-85168491
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  • Yongguo Wang,

    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
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  • Chunqiu Zhang,

    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
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  • Wei Lu,

    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
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  • Jiayun Xu,

    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
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  • Junqiu Liu

    Corresponding author
    1. Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China
    • Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun, Jilin 130012, China, Tel.: 0086-0431-85168452; Fax: 0086-0431-85168491
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Abstract

Cucurbituril (CB), a well-known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host-guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self-assemble into well-defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1-adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.

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