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Keywords:

  • sorafenib analogs;
  • diaryl thiourea;
  • structure-activity relationships;
  • antiproliferative activity

Abstract

Two new series of diaryl thiourea containing sorafenib derivatives 9a9t were designed and synthesized, and their antiproliferative activities against PC-3, HCT116 and MDA-MB-231 cell lines were evaluated. All compounds generally showed antiproliferative activity to PC-3 cells, most of the analogs exhibited potent antiproliferative activity to HCT116 cells, and compounds 9e, 9f, 9o and 9p demonstrated inhibitory activities against all three cell lines. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS.