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Keywords:

  • cyclocarbonylation;
  • 2-aminoisoindolin-1-ones;
  • multicomponent reactions;
  • heterocycles

Abstract

An efficient procedure for the synthesis of 2-aminoisoindolin-1-ones via a palladium-catalyzed three-component reaction of 2-halobenzaldehydes, hydrazines and carbon monoxide is reported. This cyclocarbonylation process can be performed smoothly under 1 atmospheric pressure of carbon monoxide to afford 2-aminoisoindolin-1-ones in moderate to excellent yields.