Synthesis and Bioactivities of Novel N-(4-(2-Aryloxythiazol-5-yl)but-3-yn-2-yl)benzamides

Authors

  • Youquan Zhu,

    Corresponding author
    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    • State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Pei Liu,

    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Danyang Wang,

    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Jin Zhang,

    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Jie Cheng,

    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Yuan Ma,

    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Xiaomao Zou,

    Corresponding author
    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    • State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author
  • Huazheng Yang

    1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
    Search for more papers by this author

Abstract

A series of novel N-(4-(2-aryloxythiazol-5-yl)but-3-yn-2-yl)benzamide derivatives were designed and synthesized. Their structures were identified by 1H NMR and elemental analyses. Preliminary bioassays indicated that some title compounds provided >80% control of Sclerotinia sclerotiorum at 50 µg/mL and >70% herbicidal activities against B. campestris at 100 µg/mL. Their structure-activities relationships were also discussed.

Ancillary