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Keywords:

  • 2-aminoindole;
  • reductive cyclization;
  • Hantzsch ester;
  • palladium on carbon

Abstract

Catalytic hydrogenation of 2-cyano-2-(2-nitrophenyl)acetates bearing an electron withdrawing substituent to the nitrile, using Hantzsch ester catalyzed by Pd/C, affords 2-aminoindoles in good to excellent yields.