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Keywords:

  • diol;
  • oxidation;
  • epoxide;
  • perhydrolysis;
  • ring-opening

Abstract

The title compound was synthesized from dihydroqinghao acid via a sequential facial selective oxidative lactonization and epoxidation, a molybdenum-catalyzed perhydrolysis of the epoxy ring and dimethyl sulfide reduction of the hydroperhydroxyl functionality. Some explorations on the lactonization and ring-opening of the epoxide along with data discrepancy found with the epoxy intermediate are also presented.