A Pd(II)-Catalyzed Oxidative Cyclization for the Preparation of Aryl-Fused Six-Membered Nitrogen Heterocycles with 2-Acetoxy Functionality



A Pd(II)-catalyzed oxidative cyclization of olefinic tosylamides was developed for the preparation of aryl-fused and N-containing six-membered heterocycles. Under optimized conditions the reaction proceeded with high activity and selectivity, with yields of up to 83% being obtained. This procedure provides a facile and efficient route to the aforementioned heterocycles with 2-acetoxy functionality.