Synthesis and Evaluation of the Analogues of Penicillide against Cholesterol Ester Transfer Protein

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Abstract

A series of penicillide analogues, with modifications at C-3 and C-9 positions, are synthesized as potential cholesteryl ester transfer protein (CETP) inhibitors. The preliminary in vitro inhibition assay provided some valuable structure-activity relationship information about penicillide.

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