Facile Synthesis of 4,5-Disubstituted 2H-1,2,3-Triazoles by Catalyst-free Cycloaddition between Substituted Vinyl Sulfones and Sodium Azide under Ambient Conditions

Authors

  • Jinjin Yang,

    1. School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
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  • Wei Yin,

    1. School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
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  • Renhua Liu,

    1. School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
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  • Changhu Chu

    Corresponding author
    1. School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
    • School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
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Abstract

A highly efficient method for readily preparing 4,5-disubstituted 2H-1,2,3-triazoles was found. Under ambient conditions, a catalyst free cycloaddition between substituted vinyl sulfones and sodium azide could be completed in a very short time. In this cycloaddition process, sulfonyl group acts as a leaving group, while its ester group was retained.

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