Enantioselective Ring Opening of meso-Epoxides with Aromatic Amines Catalyzed by Dinuclear Magnesium Complexes

Authors

  • Hongli Bao,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    2. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
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  • Zheng Wang,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
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  • Tianpa You,

    1. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
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  • Kuiling Ding

    Corresponding author
    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    • State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
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Abstract

The dinuclear magnesium complexes generated in situ from the reaction of chiral multidentate semi-azacrown ether ligands with n-Bu2Mg were found to be efficient catalysts for enantioselective ring-opening of meso-epoxides with aniline derivatives, affording the corresponding chiral β-amino alcohols in good yields with up to 90% ee.

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