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Keywords:

  • meso-epoxides;
  • ring-opening;
  • asymmetric catalysis;
  • dinuclear complex;
  • magnesium

Abstract

The dinuclear magnesium complexes generated in situ from the reaction of chiral multidentate semi-azacrown ether ligands with n-Bu2Mg were found to be efficient catalysts for enantioselective ring-opening of meso-epoxides with aniline derivatives, affording the corresponding chiral β-amino alcohols in good yields with up to 90% ee.