Expedient Synthesis of (R)-Curcuphenol: A Chiral Pool Strategy

Authors

  • Jing Feng,

    1. Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China
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  • Guili Zhu,

    1. Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China
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  • Bo Liu,

    Corresponding author
    1. Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China
    2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China
    • Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China, 0086-28-8541-3712
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  • Xiangdong Zhou

    Corresponding author
    1. Department of Medicinal Chemistry, College of Pharmacy, The Third Military Medical University, Chongqing 400038, China
    • Department of Medicinal Chemistry, College of Pharmacy, The Third Military Medical University, Chongqing 400038, China
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Abstract

Curcuphenol is an interesting sesquiterpenoid with diverse bioactivities. Exploration of a concise and scalable synthetic route is still of significance in spite that many asymmetric total syntheses have been achieved. We report an expedient asymmetric synthesis of (R)-curcuphenol from citronellal, which features only two purification operations in the overall six-step synthesis.

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