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Keywords:

  • sesquiterpenoid;
  • curcuphenol;
  • total synthesis

Abstract

Curcuphenol is an interesting sesquiterpenoid with diverse bioactivities. Exploration of a concise and scalable synthetic route is still of significance in spite that many asymmetric total syntheses have been achieved. We report an expedient asymmetric synthesis of (R)-curcuphenol from citronellal, which features only two purification operations in the overall six-step synthesis.