Microbial Transformation of Pregnane-3β,16β,20-triol by Cunninghamella echinulata

Authors

  • Chenru Yang,

    1. Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
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  • Huafang Fan,

    1. Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
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  • Yuan Yuan,

    1. Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
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  • Jinming Gao

    Corresponding author
    1. Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
    • Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
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Abstract

Microbial transformation of pregnane-3β,16β,20-triol (1) by Cunninghamella echinulata afforded four previously unreported polyhydroxylated steroids, namely pregnane-3β,14α,16β,20-tetrol (2), pregnane-3-oxo-14α, 16β,20-triol (3), pregnane-3-oxo-7β,16β,20-triol (4), and pregnane-3β,7β,16β,20-tetrol (5). The structures of these metabolites were established by means of spectroscopic analysis (1D and 2D NMR as well as HRESIMS analysis).

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