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Keywords:

  • dihydroresorcylide;
  • trans-resorcylide dimethyl ether;
  • ring-closing metathesis (RCM);
  • carbonylation;
  • total synthesis

Abstract

The efficient synthesis of (S)-dihydroresorcylide (1a) along with trans-resorcylide dimethyl ether (2b), was achieved in linear 9 steps from commercially available orcinol monohydrate (6) with esterification, carbonylation, and ring-closing metathesis (RCM) as the key steps in the synthetic sequence.