Enantioselective Organocatalytic Aza-Michael Additions of Phthalimide Derivatives to α,β-Unsaturated Aldehydes

Authors

  • Shijun Ma,

    1. Department of Chemistry, The Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
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  • Ming Liu,

    1. Department of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
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  • Yaodong Huang,

    Corresponding author
    1. Department of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    • Department of Chemistry, The Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China, Tel.: 0086-022-23503281; Fax: 0086-022-23502654
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  • Yongmei Wang

    Corresponding author
    1. Department of Chemistry, The Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
    • Department of Chemistry, The Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China, Tel.: 0086-022-23503281; Fax: 0086-022-23502654
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Abstract

Phthalimide derivatives as nitrogen nucleophiles with α,β-unsaturated aldehydes for asymmetric aza-Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in good yields (up to 98%) and enantioselectivities (up to 95% ee).

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