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Keywords:

  • imidazo[1,2-a]pyridines;
  • N,S-ketene acetals;
  • multicomponent reaction;
  • domino reaction;
  • microwave irradiation

Abstract

Imidazo[1,2-a]pyridines have been successfully synthesized in moderate to good yields via a tandem three-component reaction of ethyl 2-(3-oxo-3-arylpropanethioamido)acetates with aromatic aldehydes and malononitrile by means of microwave irradiation using DABCO as the catalyst. The advantages of this method including high chemo- and regioselectivity make this new strategy highly attractive.