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Keywords:

  • cyclization reaction;
  • trifluoromethyl-1,3-diketones;
  • aryl imidoyl chlorides;
  • regioselective;
  • 3,5-bis(5- trifluoromethyl-isoxazol)-pyridine derivatives

Abstract

Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0°C to give 2,6-dimethyl-3,5-bis(4,4,4-trifluoro-1,3-oxo-butyl)-pyridine (2a) in good yield. Cyclization reaction of 2a and aryl imidoyl chlorides 5a5i, obtained from chlorination of aryl oximes with N-chlorosuccimide, afforded 2,6-dimethyl-3,5-bis[(3-aryl-5-trifluoromethyl)-isoxazol-4-carbonyl]-pyridine derivatives 6a6i.