Synthesis of β-Cyclodextrin-[60]fullerene Conjugate and Its DNA Cleavage Performance

Authors

  • Jingjing Wang,

    1. Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China
    2. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China
    Search for more papers by this author
  • Zhaoheng Zhang,

    1. Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China
    Search for more papers by this author
  • Wei Wu,

    Corresponding author
    1. Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China
    • Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China, Tel.: 0086-025-83597138

    Search for more papers by this author
  • Xiqun Jiang

    Corresponding author
    1. Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China
    • Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China, Tel.: 0086-025-83597138

    Search for more papers by this author

Abstract

A water soluble β-cyclodextrin (β-CD) functionalized [60]fullerene (C60-CD) was synthesized. The C60-CD-induced generation of reactive oxygen species (ROS), and DNA-cleavage ability and cytotoxicity of C60-CD were studied upon visible light irradiation, demonstrating that the compound is very promising in the applications of photodynamic therapy. The histological analyses demonstrate that C60-CD has no acute or subacute toxicity to living body.

Ancillary