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Keywords:

  • pulmonary delivery systems;
  • drugs and genes delivery;
  • lung disease;
  • therapeutic efficacy

Abstract

Pulmonary drugs and genes delivery systems have become an attractive approach in the treatment of lung diseases with the advantages of minimal drug loss, precise quantization, high local drugs concentration and low side effects. However, special attention should be paid to the biological barriers of the lung. The delivery systems need to be designed carefully in order to overcome these biological barriers and maximize the drugs and genes deposition to the lungs. Pulmonary drugs and genes delivery systems can offer some encouraging results for delivering drugs and genes to the lungs. Specifically, some lipid-based and polymer-based delivery systems could control and sustain the release of drugs and genes with minimal or negligible toxicity. This review focuses on the latest development of pulmonary delivery of drugs and genes for the treatment of various lung diseases. The barriers to the lung, the delivery devices, the route of the administration and the delivery systems for drugs and genes pulmonary delivery are described. Based on the rapid development of clinical requirement, novel approaches using delivery systems for pulmonary delivery drugs and genes need to be constructed, which is believed to play an important role in the therapy of lung diseases in the future.