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Keywords:

  • dendrimer;
  • magnetic resonance imaging;
  • biodegradable;
  • tumor imaging

Abstract

Novel biodegradable dendritic contrast agents (DCAs) based on polyester dendrimers were synthesized and characterized. The DCAs were stable at acidic pH, but hydrolyzed rapidly at physiological pH, which rendered the DCA's long-term Gd3+ retention as low as that of small molecule CAs. Their longitudinal relaxivities of 10.2 to 17.5 L·mmol−1·s−1 were about 2.4 to 4.1 times higher than that of DTPA-Gd, indicating their superior contrast-enhancing capability to the clinically used contrast agent. The in vivo MRI study suggested that the DCA at lower generation (G2-DTPA-Gd) could effectively enhance the MRI of tumor, while the one at higher generation (G5-DTPA-Gd) showed more potential in liver imaging.