Multicomponent Reactions for Diverse Synthesis of N-Substituted and NH 1,4-Dihydropyridines

Authors

  • Jieping Wan,

    Corresponding author
    1. Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
    • Jieping Wan, Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China, Fax: 0086-0791-88120380

      Chengping Wen, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

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  • Youyi Zhou,

    1. Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
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  • Yunyun Liu,

    1. Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
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  • Zheng Fang,

    1. Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
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  • Chengping Wen

    Corresponding author
    1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
    • Jieping Wan, Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China, Fax: 0086-0791-88120380

      Chengping Wen, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

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Abstract

The multicomponent reactions of aldehydes, electron deficient alkynes and amines have been successfully performed to yield a number of symmetrical 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs). This method has been found generally applicable for the synthesis of both N-substituted and N-unsubstituted 1,4-DHPs by employing secondary amine to activate the alkyne component via enaminoester intermediates. The present method runs through an enamine type activation, which is different from the known approach employing AcOH as solvent.

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