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Keywords:

  • hyperbranched supramolecular polymer;
  • host-guest system;
  • cyclodextrin;
  • Mn-porphyrin;
  • MRI

Abstract

A hyperbranched supramolecular polymer (HSP) is constructed based on the intermolecular inclusion complexation of bridged tris(permethyl-β-cyclodextrin) with MnIII-porphyrin bearing poly(ethylene glycol) (PEG) side chains (MnIII-TPP), and characterized by UV/vis absorption spectroscopy, isothermal titration calorimetry (ITC), NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM), respectively. The presence of permethyl-β-cyclodextrin can stabilize the low-valent MnII-TPP. In vitro cell experiment indicates that this HSP has no remarkable cellular toxicity against NIH 3T3 cells. In vitro MR imaging experiment indicates a slightly increased T1 relaxivity for this HSP compared to that for the linear supramolecular polymer.