Hyperbranched Supramolecular Polymer of Tris(permethyl-β-cyclodextrin)s with Porphyrins: Characterization and Magnetic Resonance Imaging

Authors

  • Mo Sun,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China
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  • Hengyi Zhang,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China
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  • Xinyue Hu,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China
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  • Bowen Liu,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China
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  • Yu Liu

    Corresponding author
    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China
    • Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China, Tel.: 0086-022-23503625; Fax: 0086-022-23503625

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Abstract

A hyperbranched supramolecular polymer (HSP) is constructed based on the intermolecular inclusion complexation of bridged tris(permethyl-β-cyclodextrin) with MnIII-porphyrin bearing poly(ethylene glycol) (PEG) side chains (MnIII-TPP), and characterized by UV/vis absorption spectroscopy, isothermal titration calorimetry (ITC), NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM), respectively. The presence of permethyl-β-cyclodextrin can stabilize the low-valent MnII-TPP. In vitro cell experiment indicates that this HSP has no remarkable cellular toxicity against NIH 3T3 cells. In vitro MR imaging experiment indicates a slightly increased T1 relaxivity for this HSP compared to that for the linear supramolecular polymer.

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