New Ligands for Copper-Catalyzed C[BOND]N Coupling Reactions at Gentle Temperature

Authors

  • Jinyue Su,

    1. Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu 210009, China
    2. Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, Guangzhou, Guangdong 510530, China
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  • Yatao Qiu,

    1. Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, Guangzhou, Guangdong 510530, China
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  • Sheng Jiang,

    Corresponding author
    1. Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, Guangzhou, Guangdong 510530, China
    • Sheng Jiang, Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, Guangzhou, Guangdong 510530, China, Fax: 0086-020-32015318

      Dayong Zhang, Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

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  • Dayong Zhang

    Corresponding author
    1. Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu 210009, China
    • Sheng Jiang, Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, Guangzhou, Guangdong 510530, China, Fax: 0086-020-32015318

      Dayong Zhang, Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

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Abstract

Pyridin-2-ol-N-oxide was designed as an efficient ligand for the coupling reaction of aryl iodides, aryl bromides and aryl chlorides, respectively, with primary amines, cyclic secondary amines or N-containing heterocycles at room or moderate temperature. The catalytic system showed great functional groups tolerance and excellent selective reactivity.

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