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Keywords:

  • Michael addition-Lactonization;
  • dihydrobenzofuran;
  • Fc-PIP

Abstract

A highly enantioselective intramolecular Michael addition-Lactonization domino reaction of a range of enon acids catalyzed by nuleophilic organocatalyst (Fc-PIP) was developed, furnishing cis-2,3-dihydrobenzofuran derivatives with excellent enantioselecitivities (94%–98% ee) and good diastereoselectivities (up to 99/1).