A novel malonamide-linked zinc bisporphyrinate [Zn2-1] has been designed and synthesized. UV-vis and NMR spectroscopic studies suggest the molecule aggregates in solution. Such zinc bisporphyrinate is very CD-sensitive when it is mixed with amino acid ethyl esters. The amplitude value of the induced circular dichroism (ICD) is up to ca. 1500 L·mol−1·cm−1. Further studies by 1H NMR and UV-vis spectroscopies reveal amino acid esters function as monodentate ligands, and [Zn2-1] interacts with amino acid ethyl esters through coordination and hydrogen bonding interactions.