• supramolecular assemblies;
  • fluorescent sensor;
  • heparin;
  • protein;
  • interaction
Thumbnail image of graphical abstract

The cover picture shows a label-free fluorescent sensor for probing the interaction between heparin and protein. Heparin, the bioactive polyanions, formed supramolecular assemblies with cationic surfactant CTAB. The environment-dependent dye pyrene, encapsulated in hydrophobic interiors of the supramolecular assemblies works as the fluorescence probe. Once the target protein was added, heparin would be taken away by protein, resulting in the release of the sequestered pyrene and subsequently decrease of fluorescence intensity. Such a strategy is appealing as organic synthesis is traded off against supramolecular assembly. The binding events were exemplified by protamine and Tat peptide and these processes were also verified by DLS and TEM. This label-free fluorescent system is simple, selective, convenient, also this method has the potential for preprimary drug screening. More details are discussed in the article by Ji et al. on page 85–90.