Electrospray Ionization Mass Spectra of Dipeptide Derivatives (pages 1333–1338)
Zaigang LUO, Chengchu ZENG, Daoshan YANG, Yali HUANG, Fang WANG, Hongguang DU and Liming HU
Version of Record online: 24 JUL 2009 | DOI: 10.1002/cjoc.200990223
Dipeptide derivatives, as a type of HIV integrase inhibitor, were synthesized, and their fragmentation pathways were investigated by electrospray ionization mass spectrometry (ESI-MSn) in conjunction with tandem mass spectrometry (MS/MS). In order to better understand the fragmentation pathways, the MS2 and MS3 spectra of the title compound were obtained. The main fragmentation pathways occur by the cleavage of the C–CO bonds between N-(benzothiazol-2-yl) aminocarbonyl and methylene, NH–CO bonds between the NH groups and carbonyl groups (CO–NH amido bonds).