Synthesis and Insecticidal Activities of Novel Phthalic Acid Diamides (pages 1445–1452)
Tao Yan, Yuxin Li, Yongqiang Li, Duoyi Wang, Wei Chen, Zhuo Liu and Zhengming Li
Article first published online: 7 MAY 2012 | DOI: 10.1002/cjoc.201100746
In order to discover novel insecticides with the new action mode on RyR, a series of novel phthalic acid diamide derivatives were designed and synthesized. All compounds were characterized by 1H NMR spectra and HRMS. The preliminary results of biological activity assessment indicated that some title compounds exhibited excellent insecticidal activities against Mythimna separata, Spodoptera exigua, and Plutella xylostella. The title compound 3-nitro-N-cyclopropyl-N′-[2-methyl-4-(perfluoropropan-2-yl)-phenyl]-phthalamide (4a) was more efficient against diamondback moths than the control (chlorantraniliprole). The effects of some title compounds on intracellular calcium of neurons from the Spodoptera exigua proved that the title compounds were RyR activators.