Chinese Journal of Chemistry

Cover image for Vol. 32 Issue 5

May, 2014

Volume 32, Issue 5

Pages 373–453

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Communication
    6. Full Papers
    7. Note
    1. You have free access to this content
      Cover Picture: Derivation of Oridonin with Bioreduction-Responsive Disulfide Bond (Chin. J. Chem. 5/2014) (page 373)

      Ming Du, Qisang Guo, Hua Feng, Guolin Lu and Xiaoyu Huang

      Version of Record online: 23 MAY 2014 | DOI: 10.1002/cjoc.201490010

      Thumbnail image of graphical abstract

      The cover picture shows the synthesis of a novel oridonin derivative with bioreduction-responsive disulfide bond. Oridonin, isolated from the leaves of traditional Chinese herb Isodon rubescens, has anti-tumor, anti-viral, anti-bacterial, and anti-in?ammatory effects. Because of its relatively moderate potency and limited aqueous solubility, oridonin-based structural modification is needed to obtain oridonin derivatives with higher potency and improved solubility. Starting from commercially available natural product oridonin, the practical synthesis of oridonin derivative was accomplished via two alternative routes. A bioreduction-responsive disulfide bond and two hydroxyls were introduced at 14-OH position of oridonin. The bio-reductive responsiveness of disulfide bond in the oridonin derivative was verified by reverse phase HPLC under the presence of glutathione. More details are discussed in the article by Du et al. on page 448–453.

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Communication
    6. Full Papers
    7. Note
    1. You have free access to this content
  3. Communications

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Communication
    6. Full Papers
    7. Note
    1. Facile Synthesis of 4-H-Pyran Derivatives Bearing Indole Skeleton via [3+3] Cyclization of 3-Indolyl-3-oxopropanenitriles with Dialkyl Acetylenedicarboxylates and Isocyanides (pages 381–386)

      Ping Song, Lili Zhao and Shunjun Ji

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400155

      Thumbnail image of graphical abstract

      An efficient multicomponent reaction of 3-indolyl-3-oxopropanenitriles with dialkyl acetylenedicarboxylates and isocyanides under mild conditions leading to highly functionalized 6-(indol-3-yl)-4H-pyrans in moderate to good yields has been developed.

    2. Catalytic C[BOND]N Bond Alkynylation of N-Benzylic Sulfonamides with Terminal Alkynes (pages 387–390)

      Congrong Liu, Fulai Yang and Tingting Wang

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400194

      Thumbnail image of graphical abstract

      An unprecedented synthesis of internal alkynes from N-benzylic sulfonamides and terminal alkynes has been developed through TfOH/Fe(OTf)3-catalyzed cleavage of C(sp3)[BOND]N bonds and C(sp)[BOND]H bonds. This protocol is compatible with a broad range of N-benzylic sulfonamides and arylacetylenes.

    3. Evidence for a Bulky Unit of a Pillar[5]arene Flipping in the Solid State (pages 391–395)

      Mingguang Pan and Min Xue

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400204

      Thumbnail image of graphical abstract

      This paper reported an interesting finding on the conformation of a pillar[5]arene derivative: a bulky unit (1,4-methoxycarbonylmethoxybenzene unit) also flipped in the solid state. The driving force to this phenomenon may be hydrogen bonding.

  4. Communication

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Communication
    6. Full Papers
    7. Note
    1. Green Recyclable CuO-CeO2 Nanocomposite Catalyzed Amination of Aryl Halides with Aqueous Ammonia in Water (pages 396–398)

      Jalal Albadi and Azam Mansournezhad

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400138

      Thumbnail image of graphical abstract

      Efficient procedure for the amination of aryl halides catalyzed by Cu-CeO2 nanocomposite.

  5. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Communication
    6. Full Papers
    7. Note
    1. A Study of Electron Beam Induced Deposition and Nano Device Fabrication Using Liquid Cell TEM Technology (pages 399–404)

      Xin Chen, Lihui Zhou, Ping Wang, Hongliang Cao, Xiaoli Miao and Feifei Wei

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400139

      Thumbnail image of graphical abstract

      Individual SiCx nano features have been made using in situ liquid cell TEM with electron beam induced deposition (EBID) method, and subsquently fabricated into nano devices with ex situ focused ion beam (FIB) electrode deposition.

    2. 4-Benzamido-TEMPO Catalyzed Oxidation of a Broad Range of Alcohols to the Carbonyl Compounds with NaBrO3 under Mild Conditions (pages 405–409)

      Jiaxuan Shen, Jiangkai Sun, Shuangshuang Qin, Changhu Chu and Renhua Liu

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400141

      Thumbnail image of graphical abstract

      4-Benzamido-TEMPO catalyzed oxidation system for conversion of a wide range of alcohols to the aldehydes or ketones with NaBrO3 as oxidant under room temperature conditions has been developed.

    3. Efficient Extractive Desulfurization of Fuel Oils Using N-Pyrrolidone/Alkylphosphate-Based Ionic Liquids (pages 410–416)

      Chunhai Liu, Qihui He, Zheng Zhang, Yangyang Su, Renfu Xu and Baixing Hu

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400146

      Thumbnail image of graphical abstract

      An efficient approach for extractive desulfurization by ionic liquids (ILs) based on N-pyrrolidone and alkylphosphate is described. These ILs have high extracting ability of sulfur compounds under mild extraction conditions and excellent multiple extraction and regeneration performance.

    4. Organocatalytic Stereoselective Synthesis of 3-Alkyl-3-hydroxy-2-oxindoles Catalyzed by Novel Water-compatible Axially Unfixed Biaryl-based Bifunctional Organocatalysts (pages 417–428)

      Hongwu Zhao, Wei Meng, Zhao Yang, Ting Tian, Zhihui Sheng, Hailong Li, Xiuqing Song, Yutong Zhang, Sen Yang and Bo Li

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400166

      Thumbnail image of graphical abstract

      Catalyzed by axially unfixed biaryl-based bifunctional organocatalys 5a, the direct aldol reactions of isatins with ketones provided a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives in high chemical yields (up to >99%) with excellent stereoselectivities (up to >99:1 dr and >99% ee).

    5. A Highly Selective and Sensitive Fluorescent Chemosensor for Detection of Al3+ in Totally Aqueous Media (pages 429–433)

      Xiaobo Li, Jiayi Chen and Enju Wang

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400121

      Thumbnail image of graphical abstract

      The chemosensor exhibits a sensitive fluorescence response specific to Al3+ in water under weak acid conditions and the fluorescence response is visible under natural light.

    6. Production of 5-Hydroxymethylfurfural from Fructose in Ionic Liquid Efficiently Catalyzed by Cr(III)-Al2O3 Catalyst (pages 434–442)

      Changhua Song, Hui Liu, Yuan Li, Shuai Ge, Hongwei Wang, Wenshuai Zhu, Yonghui Chang, Changri Han and Huaming Li

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400054

      Thumbnail image of graphical abstract

      The schematic diagram for fructose dehydration to HMF on Cr(III)-Al2O3 catalyst.

    7. Synthesis and Antitumor Activity Evaluation of Pyrimidine Analogues Bearing Urea Moiety (pages 443–447)

      Kunpeng Shao, Xuyao Zhang, Xiaosong Zhang, Dengqi Xue, Liying Ma, Qiurong Zhang and Hongmin Liu

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201400095

      Thumbnail image of graphical abstract

      A series of 4-anilino-6-phenylpyrimidines containing urea moiety were synthesized. The antiproliferative activities of these compounds were evaluated against three human tumor cell lines (MGC-803, MCF-7 and EC-109) by applying the MTT assay method. compounds 4a, 4b and 6a showed most effective activity, among which, 6a was more cytotoxic than 5-fluorouracil against all tested three human cancer cell lines with IC50 values ranging from 1.80 to 2.72 µmol·L−1.

  6. Note

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Communication
    6. Full Papers
    7. Note
    1. Derivation of Oridonin with Bioreduction-Responsive Disulfide Bond (pages 448–453)

      Ming Du, Qisang Guo, Hua Feng, Guolin Lu and Xiaoyu Huang

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/cjoc.201300761

      Thumbnail image of graphical abstract

      A novel oridonin derivative with bioreduction-responsive disulfide bond was synthesized and leads to high leaving ability of the 14-O acyl moiety when treated with glutathione.

SEARCH

SEARCH BY CITATION