Clinical Investigation

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Assessment of Regional Systolic and Diastolic Functions Affected by Atorvastatin in Coronary Artery Disease Using Tissue Doppler Imaging

  1. Liangyi Qie MD, PhD1,
  2. Xiao Meng MD2,
  3. Yubin Wang MD3,
  4. Min Feng PhD4,
  5. Ming Zhong PhD4,
  6. Li Li MD, PhD4,*

Article first published online: 25 AUG 2008

DOI: 10.1002/clc.20287

Issue

Clinical Cardiology

Clinical Cardiology

Volume 31, Issue 11, pages 551–555, November 2008

Additional Information

How to Cite

Qie, L., Meng, X., Wang, Y., Feng, M., Zhong, M. and Li, L. (2008), Assessment of Regional Systolic and Diastolic Functions Affected by Atorvastatin in Coronary Artery Disease Using Tissue Doppler Imaging. Clinical Cardiology, 31: 551–555. doi: 10.1002/clc.20287

Author Information

  1. 1

    Department of Health Care, Qilu Hospital, Shandong University;

  2. 2

    Department of Cardiology, The Fourth People's Hospital of Jinan, Jinan;

  3. 3

    Department of Cardiology, Affiliated Hospital of Weifang Medical College, Weifang;

  4. 4

    Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China

*Department of Cardiology QiLu Hospital Shandong University Jinan, China

Publication History

  1. Issue published online: 12 NOV 2008
  2. Article first published online: 25 AUG 2008
  3. Manuscript Accepted: 20 AUG 2007
  4. Manuscript Received: 26 JUL 2007

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Keywords:

  • tissue Doppler imaging;
  • atorvastatin;
  • left ventricle;
  • systolic function;
  • diastolic function

Abstract

Background

Several studies have shown regional left ventricular (LV) systolic and diastolic changes associated with coronary artery disease (CAD). Statins may have beneficial pleiotropic effects in addition to their lipid-lowering properties.

Hypothesis

We hypothesized that atorvastatin can improve regional LV systolic and diastolic functions in CAD patients using tissue Doppler imaging (TDI).

Methods

A total of 63 patients with hyperlipemia and CAD were studied. Forty-three patients were given 10 mg daily of atorvastatin and 20 patients were assigned only a low-fat diet. Tissue Doppler imaging was applied to evaluate LV peak systolic velocity (VS), early diastolic velocity (VE), and late diastolic velocity (VA) in 18 segments. The mean value of LV peak systolic velocity (VS′), the mean value of early diastolic velocity (VE′), and the mean value of late diastolic velocity (VA′), in 18 segments were calculated.

Results

Compared with the baseline, VS′, and VE′, increased significantly after the therapy in the atorvastatin group (p < 0.05), while there was no change in the control group (p > 0.05). At 6 mo of therapy, a significant reduction in total cholesterol, triglyceride, and low-density lipoprotein (LDL) cholesterol was observed in the 2 groups (p < 0.05).

Conclusions

These findings demonstrate that atorvastatin can improve regional LV systolic and diastolic functions in CAD patients independent of its lipid-lowering properties. Copyright © 2008 Wiley Periodicals, Inc.

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