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Impact of Preprocedural High-Sensitivity C-Reactive Protein Levels on Uncovered Stent Struts: An Optical Coherence Tomography Study After Drug-Eluting Stent Implantation

  1. Byeong-Keuk Kim MD1,
  2. Jung-Sun Kim MD1,
  3. Changmyung Oh MD1,
  4. Young-Guk Ko MD1,
  5. Donghoon Choi MD1,
  6. Yangsoo Jang MD1,2,
  7. Myeong-Ki Hong MD1,2,*

Article first published online: 6 FEB 2011

DOI: 10.1002/clc.20856

Issue

Clinical Cardiology

Clinical Cardiology

Volume 34, Issue 2, pages 97–101, February 2011

Additional Information

How to Cite

Kim, B.-K., Kim, J.-S., Oh, C., Ko, Y.-G., Choi, D., Jang, Y. and Hong, M.-K. (2011), Impact of Preprocedural High-Sensitivity C-Reactive Protein Levels on Uncovered Stent Struts: An Optical Coherence Tomography Study After Drug-Eluting Stent Implantation. Clin Cardiol, 34: 97–101. doi: 10.1002/clc.20856

Author Information

  1. 1

    Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea

  2. 2

    Severance Biomedical Science Institute (Jang, Hong), Yonsei University College of Medicine, Seoul, Korea

*Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea

Publication History

  1. Issue published online: 4 FEB 2011
  2. Article first published online: 6 FEB 2011
  3. Manuscript Accepted: 11 OCT 2010
  4. Manuscript Received: 12 SEP 2010

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Abstract

Background

There are no sufficient data to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and uncovered stent struts on optical coherence tomography (OCT) after drug-eluting stent (DES) implantation.

Hypothesis

We evaluated the relationship between the preprocedural level of hs-CRP and incomplete neointimal coverage of DES struts on OCT.

Methods

This study was conducted using 124 eligible patients (132 lesions) treated with sirolimus-eluting stents (SES) or zotarolimus-eluting stents (ZES). The subjects were divided into 2 groups based on the preprocedural hs-CRP level: high-CRP (≥3 mg/L; 58 lesions) and normal-CRP (<3 mg/L, 74 lesions) groups. The percentage of uncovered struts, calculated as the ratio of uncovered struts to total struts in all OCT cross-sections, was compared between the 2 groups according to initial clinical presentation (stable angina [SA] vs acute coronary syndrome) and the type of implanted DES (SES vs ZES).

Results

There was no significant correlation between hs-CRP and the percentage of uncovered struts on OCT in all enrolled lesions. In the SA subgroup, the percentage of uncovered struts was significantly higher in the high-CRP group than in the normal-CRP group (8.1 ± 11.6% vs 3.8 ± 7.9%, P = 0.018). There was significant correlation between hs-CRP level and the percentage of uncovered struts in SA patients with SES (r = 0.280, P = 0.039), but not ZES (r = − 0.063, P = 0.729).

Conclusions

Preprocedural hs-CRP level could affect incomplete neointimal coverage of struts after DES implantation depending on the initial clinical presentation and the type of implanted DES. Copyright © 2011 Wiley Periodicals, Inc.

This study was partly supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (No. A085012 and A102064), the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (No. A085136), and the Cardiovascular Research Center, Seoul, Korea. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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