• 1.
    Lebowitz NE, Bella JN, Roman MJ, et al. Prevalence and correlates of aortic regurgitation in American Indians: the Strong Heart Study. J Am Coll Cardiol. 2000;36:461467.
  • 2.
    Ross J Jr. Adaptations of the left ventricle to chronic volume overload. Circ Res. 1974;35(suppl II):6470.
  • 3.
    Bonow RO, Carabello BA, Chatterjee K, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol. 2006;48:e1e148.
  • 4.
    Bonow RO, Lakatos E, Maron BJ, et al. Serial long-term assessment of the natural history of asymptomatic patients with chronic aortic regurgitation and normal left ventricular systolic function. Circulation. 1991;84:16251635.
  • 5.
    Kleaveland JP, Reichek N, McCarthy DM, et al. Effects of six-month afterload reduction therapy with hydralazine in chronic aortic regurgitation. Am J Cardiol. 1986;57:11091116.
  • 6.
    Greenberg B, Massie B, Bristow JD, et al. Long-term vasodilator therapy of chronic aortic insufficiency: a randomized double-blinded, placebo-controlled clinical trial. Circulation. 1988;78:92103.
  • 7.
    Scognamiglio R, Fasoli G, Ponchia A, et al. Long-term nifedipine unloading therapy in asymptomatic patients with chronic severe aortic regurgitation. J Am Coll Cardiol. 1990;16:424429.
  • 8.
    Wilson R, Perlmutter N, Jacobson N, et al. Effects of long-term vasodilator therapy on electrocardiographic abnormalities in chronic aortic regurgitation. Am J Cardiol. 1991;68: 935939.
  • 9.
    Scognamiglio R, Rahimtoola SH, Fasoli G, et al. Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. N Engl J Med. 1994;331:689694.
  • 10.
    Sondergaard L, Aldershvile J, Hildebrandt P, et al. Vasodilatation with felodipine in chronic asymptomatic aortic regurgitation. Am Heart J. 2000;139:667674.
  • 11.
    Evangelista A, Tornos P, Sambola A, et al. Long-term vasodilator therapy in patients with severe aortic regurgitation. N Engl J Med. 2005;353:13421349.
  • 12.
    Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet. 1999;354:18961900.
  • 13.
    Harris RP, Helfand M, Woolf SH, et al. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001;20(3 suppl):2135.
  • 14.
    Siemienczuk D, Greenberg B, Morris C, et al. Chronic aortic insufficiency factors associated with progression to aortic valve replacement. Ann Intern Med. 1989;110:587592.
  • 15.
    Borer JS, Hochreiter C, Herrold EM, et al. Prediction of indications for valve replacement among asymptomatic or minimally symptomatic patients with chronic aortic regurgitation and normal left ventricular performance Circulation. 1998;97:525534.
  • 16.
    Tarasoutchi F, Grinberg M, Spina GS, et al. Ten-year clinical laboratory follow-up after application of a symptom-based therapeutic strategy to patients with severe chronic aortic regurgitation of predominant rheumatic etiology. J Am Coll Cardiol. 2003;41:13161324.
  • 17.
    Uretsky S, Supariwala A, Nidadovolu P, et al. Quantification of left ventricular remodeling in response to isolated aortic or mitral regurgitation. J Cardiovasc Magn Reson. 2010;12:32.
  • 18.
    Dujardin KS, Enriquez-Sarano M, Rossi A, et al. Echocardiographic assessment of left ventricular remodeling: are left ventricular diameters suitable tools [published correction appears in J Am Coll Cardiol. 1998;31:240]? J Am Coll Cardiol. 1997;30:15341541.
  • 19.
    Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest. 1975;56: 5664.
  • 20.
    Wisenbaugh T, Spann JF, Carabello BA. Differences in myocardial performance and load between patients with similar amounts of chronic aortic versus chronic mitral regurgitation. J Am Coll Cardiol. 1984;3:916923.
  • 21.
    Bonow RO, Dodd JT, Maron BJ, et al. Long-term serial changes in left ventricular function and reversal of ventricular dilatation after valve replacement for chronic aortic regurgitation. Circulation. 1988;78:11081120.
  • 22.
    Chaliki HP, Mohty D, Avierinos JF, et al. Outcomes after aortic valve replacement in patients with severe aortic regurgitation and markedly reduced left ventricular function. Circulation. 2002;106:26872693.
  • 23.
    Bonow RO, Rosing DR, Maron BJ. Reversal of left ventricular dysfunction after aortic valve replacement for chronic aortic regurgitation: influence of duration of preoperative left ventricular dysfunction. Circulation. 1984;70:570579.
  • 24.
    Dujardin KS, Enriquez-Sarano M, Schaff HV, et al. Mortality and morbidity of aortic regurgitation in clinical practice: a long-term follow-up study. Circulation 1999;99:18511857.
  • 25.
    Mahajerin A, Gurm HS, Tsai TT, et al. Vasodilator therapy in patients with aortic insufficiency: a systematic review. Am Heart J. 2007;153:454461.
  • 26.
    Elder DH, Wei L, Szwejkowski BR, et al. The impact of renin-angiotensin-aldosterone system blockade on heart failure outcomes and mortality in patients identified to have aortic regurgitation: a large population cohort study. J Am Coll Cardiol. 2011;58:20842091.