Association Between Tp-e/QT Ratio and Prognosis in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction

Authors

  • Xiangmei Zhao MS,

    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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  • Zhouliang Xie BS,

    1. Department of Cardiac Surgery, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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  • Yingjie Chu PhD,

    Corresponding author
    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
    • Yingjie Chu, PhD Department of Emergency Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University) Zhengzhou 450003, China
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  • Lei Yang MS,

    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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  • Wenkai Xu MS,

    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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  • Xianzhi Yang BS,

    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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  • Xiaoyu Liu MS,

    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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  • Lixiao Tian MS

    1. Department of Emergency, Henan Provincial People's Hospital (The People's Hospital of Zhengzhou University), Zhengzhou, China
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Abstract

Background:

Both the Tpeak-Tend interval (Tp-e) and the Tp-e/QT ratio have been linked to increased risk for arrhythmia. Patient Tp-e/QT ratios were investigated prior to primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI).

Hypothesis:

Tp-e/QT ratio maybe asscioated with the prognosis in patients with ST-segment elevation.

Methods:

A total of 338 patients (N = 338) with STEMI treated by pPCI were included. The Tp-e and Tp-e/QT ratio were determined using electrocardiograms in the subjects exhibiting ST-segment elevation.

Results:

The Tp-e/QT ratio was correlated with both short- and long-term outcomes. Analysis of the receiver operating characteristic curve demonstrated that the optimal cutoff value for outcome prediction was a Tp-e/QT ratio of 0.29. Of the 388 patients enrolled, 115 (34.0%) exhibited a Tp-e/QT ratio ≥0.29. Patients with a Tp-e/QT ratio ≥0.29 showed elevated rates of both in-hospital death (21.9% vs 2.3%; P < 0.001) and main adverse cardiac events (MACE) (48.1% vs 15.3%; P < 0.005). After discharge, Tp-e/QT ratios ≥0.29 remained an independent predictor of all-cause death (35.5% vs 5.2%, P < 0.001) and cardiac death (32.3% vs 2.6%, P < 0.001).

Conclusions:

The Tp-e/QT ratio may serve as a prognostic predictor of adverse outcomes after successful pPCI treatment in STEMI patients. Clin. Cardiol. 2012 doi: 10.1002/clc.22022

This work was supported by grants from the Henan Provincial People's Hospital. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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