Thanos Athanasiou proposed the original concept for the study and supervised this research. Jacob Chacko and Leanne Harling performed the literature search, and wrote and edited the manuscript. Data analysis was performed by Leanne Harling and Hutan Ashrafian. Leanne Harling, Hutan Ashrafian, and Thanos Athanasiou together edited and finalized the manuscript. All authors have read and approved the manuscript prior to submission.
Can Statins Improve Outcomes After Isolated Cardiac Valve Surgery? A Systematic Literature Review
Version of Record online: 13 MAY 2013
© 2013 Wiley Periodicals, Inc.
Volume 36, Issue 8, pages 448–455, August 2013
How to Cite
Chacko, J., Harling, L., Ashrafian, H. and Athanasiou, T. (2013), Can Statins Improve Outcomes After Isolated Cardiac Valve Surgery? A Systematic Literature Review. Clin Cardiol, 36: 448–455. doi: 10.1002/clc.22140
The authors have no funding, financial relationships, or conflicts of interest to disclose.
- Issue online: 12 AUG 2013
- Version of Record online: 13 MAY 2013
- Manuscript Revised: 11 APR 2013
- Manuscript Received: 24 MAR 2013
HMG CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors, or statins, have been associated with an improvement in outcomes after coronary artery surgery for some time; however, their role in isolated valve surgery (IVS) remains undetermined.
The pleiotropic effects of statins may produce similar beneficial effects on outcomes after IVS.
A systematic review of the literature was performed investigating the role of statins in bioprosthetic valve replacement.
Nine observational studies (7 retrospective, 2 prospective) incorporating a total of 18 154 patients were found investigating the role of statin therapy in bioprosthetic valve replacement.
There is presently insufficient evidence to recommend routine statin therapy in IVS, unless concomitant hypercholesterolemia or coronary artery disease is present. A prospective study clearly defining the dose, type, and duration of therapy is now required to finally clarify whether statins alone confer a postoperative benefit in these patients.