Dr. Brown is supported by grant number K01HS018443 from the Agency for Healthcare Research and Quality. Funding for the STEMI registry is supported by the Section of Cardiology, Dartmouth-Hitchcock Medical Center.
Quality and Outcome
Predicting Readmission or Death After Acute ST-Elevation Myocardial Infarction
Article first published online: 10 JUN 2013
© 2013 Wiley Periodicals, Inc.
Volume 36, Issue 10, pages 570–575, October 2013
How to Cite
Brown, J. R., Conley, S. M. and Niles, N. W. (2013), Predicting Readmission or Death After Acute ST-Elevation Myocardial Infarction. Clin Cardiol, 36: 570–575. doi: 10.1002/clc.22156
The authors have no other funding, financial relationships, or conflicts of interest to disclose.
- Issue published online: 9 OCT 2013
- Article first published online: 10 JUN 2013
- Manuscript Revised: 11 MAY 2013
- Manuscript Received: 15 MAR 2013
Risk factors for emergent readmissions or death after acute myocardial infarction (AMI) are important in identifying patients at risk for major adverse events. However, there has been limited investigation conducted of prospective clinical registries to determine relevant risk factors.
We hypothesize 30-day readmission or death could be predicted using patient, procedural, and process factors.
Patients presenting with ST-elevation myocardial infarction (STEMI) from 2006 to 2011 were prospectively enrolled in a STEMI registry (1271 patients). Thirty-day readmission was ascertained by administrative claims data. Death was determined by linking to the Social Security Death Master File. Univariate and stepwise multivariate logistic regression was conducted with Hosmer-Lemeshow goodness-of-fit statistics for model calibration and receiver operating characteristic (ROC) curve for model discrimination.
The combined end point of 30-day readmission or postdischarge death included 135 patients (10.6%), including 109 emergent readmissions and 26 deaths. Factors associated with an increase risk of 30-day readmission or postdischarge death included age ≥80 years, diabetes, chest pain or cardiac arrest at presentation, and 3-vessel disease found at initial angiography. Factors associated with a decreased risk of 30-day readmission or postdischarge death included transfer to the catheterization lab from another emergency department, clopidogrel given during the procedure hypercholesterolemia, and receiving aspirin, β-blockers, and angiotensin-converting enzyme or angiotensin receptor blocker inhibitors at discharge. Index admission outcomes indicative of readmission or death postdischarge only included a new diagnosis of congestive heart failure. The model discriminated well with an ROC of 0.71 (95% confidence interval: 0.66-0.76).
Prehospitalization factors are overlooked and are important factors to incorporate in routine risk prediction models for readmission or death within 30 days following an AMI.