Continuous 12-lead st-segment monitoring improves identification of low-risk patients with chest pain and a worse in-hospital outcome
Article first published online: 5 DEC 2006
Copyright © 2002 Wiley Periodicals, Inc.
Volume 25, Issue 2, pages 57–62, February 2002
How to Cite
Pelliccia, F., Cianfrocca, C., Marazzi, G., Pagliei, M., Mariani, M. and Rosano, G. M. C. (2002), Continuous 12-lead st-segment monitoring improves identification of low-risk patients with chest pain and a worse in-hospital outcome. Clin Cardiol, 25: 57–62. doi: 10.1002/clc.4950250204
- Issue published online: 5 DEC 2006
- Article first published online: 5 DEC 2006
- Manuscript Accepted: 17 APR 2001
- Manuscript Received: 19 OCT 2000
- chest pain;
- electrocardiographic monitoring;
- acute myocardial infarction;
- unstable angina
Background: Various strategies have been proposed to improve diagnosis and triage of patients with chest pain at low risk, but uncertainty still exists on the optimal combination of diagnostic tools that should be used in this subset of patients.
Hypothesis: The aim of this study was to evaluate the incremental benefit of continuous 12-lead ST-segment monitoring over that provided by conventional diagnostic tools in patients with chest pain.
Methods: Of 232 consecutive patients referred because of chest pain, 52 were classified as low-risk according to the Agency for Health Care Policy and Research unstable angina guidelines and observed for 12 h with serial cardiac enzymes and electrocardiograms (ECG) (every 3 h). All patients also underwent both echocardiography at entry and continuous 12-lead ST-segment monitoring during the observation period.
Results: During a mean hospital stay of 3.7 days (range 1-14 days), a benign outcome was observed in 37 patients (71%), whereas 15 patients (29%) had major cardiac events or recurrence of chest pain of ischemic origin. Addition of ST-segment monitoring findings to baseline clinical data as well as to serial enzymes and ECG features added significant incremental prognostic value (p < 0.001). Multivariate analysis showed reproduction of pain by chest pressure (p < 0.05) and presence of ST-segment changes (≥ 0.1 mV) during 12-lead ST-segment monitoring (p < 0.001) as independent predictors of a benign or unfavorable outcome.
Conclusions: In low-risk patients with chest pain, continuous 12-lead ST-segment monitoring provides significant incremental diagnostic and prognostic information to currently used clinical, enzymatic, and ECG data, and is helpful in identifying the subset of patients with a worse in-hospital outcome.