Unrecognized left ventricular dysfunction in an apparently healthy cocaine abuse population
Version of Record online: 4 FEB 2009
Copyright © 1990 Wiley Periodicals, Inc.
Volume 13, Issue 5, pages 323–328, May 1990
How to Cite
Bertolet, B. D., Freund, G., Perchalski, D. L., Pepine, C. J., Martin, C. A. and Williams, C. M. (1990), Unrecognized left ventricular dysfunction in an apparently healthy cocaine abuse population. Clin Cardiol, 13: 323–328. doi: 10.1002/clc.4960130505
- Issue online: 4 FEB 2009
- Version of Record online: 4 FEB 2009
- Manuscript Accepted: 27 FEB 1990
- Manuscript Received: 26 DEC 1989
- myocardial infarction;
- radionuclide angiography;
- drug abuse
To determine the frequency and severity of clinically unrecognized left ventricular (LV) dysfunction related to cocaine use, 84 asymptomatic cocaine abusers underwent cardiac evaluation which included chest x-ray, electrocardiography (ECG), and radionuclide angiography after a two-week abstinence from cocaine use. LV dysfunction was discovered in 6/84 (7%). Regional wall motion abnormalities suggesting a localized myocardial abnormality were found in 2, whereas an ejection fraction <50% suggesting a more global process was noted in 4. An abnormal chest x-ray was found in only 1 subject and none had abnormal ECGs. in each of these cases, repeated and protracted use of cocaine was documented and the suggestion of cardiac dysfunction was supported by at least one other independent abnormal finding. in these 6 cases, the dysfunction was clinically unrecognized and unsuspected after routine evaluation. The significance of subclinical LV dysfunction in this population has not been determined and requires long-term study.