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Pathophysiology and therapeutic targets for ischemic stroke
Article first published online: 5 JUL 2007
DOI: 10.1002/clc.4960271404
Copyright © 2004 Wiley Periodicals, Inc.
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Clinical Cardiology
Supplement: Secondary Stroke: New Horizons in Prevention
Volume 27, Issue Supplement S2, pages 12–24, May 2004
Additional Information
How to Cite
Levine, S. R. (2004), Pathophysiology and therapeutic targets for ischemic stroke. Clin Cardiol, 27: 12–24. doi: 10.1002/clc.4960271404
Publication History
- Issue published online: 5 JUL 2007
- Article first published online: 5 JUL 2007
References
- 1, : An overview of atherosclerosis. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 324–329. San Diego, Calif.: Academic Press, 1997
- 2
- 3: Glucose and oxygen metabolism in ischemia. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 227–248. Malden, Mass.: Blackwell Science, 1998
- 4, , , , , , , , , : Occurrence of secondary ischemic events among persons with atherosclerotic vascular disease. Stroke 2002; 33: 901–906
- 5Joint National Committee: The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 1997; 24: 2413–2446
- 6, , , : Diabetic hypertension. Ensuring optimal therapy in the primary-care setting. Medical Crossfire. Available at: www.medicalcrossfire.com/debate_archive/Spec_Ed/DiabeticHypertension.htm. Accessed October 16, 2002
- 7, , , , , , , , , , , , , , , : AHA Scientific Statement. Primary prevention of ischemic stroke. Circulation 2001; 103: 163–182
- 8Scandinavian Simvastatin Survival Study Group: Randomized trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383–1389
- 9, , , , , , , , , , , : The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996; 335: 1001–1009
- 10, , , : Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 1997; 28: 946–950
- 11
- 12: Toxicity/substance abuse. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 413–416. San Diego, Calif.: Academic Press, 1997
- 13, : Pregnancy, hormonal contraception, and post-menopausal estrogen replacement therapy. In Primer on Cerebro-vascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 324–329. San Diego, Calif.: Academic Press, 1997
- 14
- 15American Stroke Association. Available at www.strokeassocia-tion.jhtm?identifier=1033. Accessed December 6, 2002.
- 16, , , , , , , , for the HERS Research Group: Postmeno-pausal hormone therapy and risk of stroke: The Heart and Estrogen-progestin Replacement Study (HERS). Circulation 2001; 103: 638–642
- 17, , , , , : A clinical trial of estrogen-replacement therapy after ischemic stroke. N Engl J Med 2001; 345: 1243–1249
- 18, , , : The effects of acute and chronic cocaine use on the heart. Circulation 1992; 85: 407–419
- 19, , , , , , , , , , , , : American Heart Association Prevention Conference. IV. Prevention and rehabilitation of stroke. Etiology of stroke. Stroke 1997; 28: 1501–1506
- 20, , : Cardioembolic stroke. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 1392–1429. Malden, Mass.: Blackwell Science, 1998
- 21, , , , , , , , , , , , : Risk factors. American Heart Association Prevention Conference. IV. Prevention and rehabilitation of stroke. Stroke 1997; 28: 1507–1517
- 22, , : Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke 1991; 22: 983–988
- 23, : Executive summary. American Heart Association Prevention Conference IV: Prevention and rehabilitation of stroke. Circulation 1997; 96: 701–707
- 24: Current epidemiology of stroke. In Current Review of Cerebrovascular Disease (Eds. FisherM, BogousslavskyJ), p. 3–14. Philadelphia, Pa.: Current Medicine, 1993
- 25: Natural history and pathophysiology of brain infarction. Circulation 1991; 83 (suppl I): I-172–I-175
- 26, , , , , , : Infarction of undetermined cause: The NINCDS Stroke Data Bank. Ann Neurol 1989; 25: 382–390
- 27, , : Pathophysiological alterations following aneurysm rupture. In Ruptured Cerebral Aneurysms: Perioperative Management. Vol. 6: Concepts in Neuro-surgery (Eds. RatchesonRA, WirthFP), p. 23–45. Baltimore, Md.: Williams and Wilkins, 1994
- 28, : Clinical aspects of subarachnoid hemorrhage. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 425–432. San Diego, Calif.: Academic Press, 1997
- 29, : Clinical aspects of intracerebral hemorrhage. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 432–436. San Diego, Calif.: Academic Press, 1997
- 30, , , , : Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg 1993; 78: 188–191
- 31. Ischemic stroke. In Handbook of Neuroepidemiology (Eds. GorelickPB, AlterM ), p. 77–119. New York, N.Y.: Marcel Dekker, 1994
- 32: Cryptogenic stroke. N Engl J Med 1988; 318: 1197–1198
- 33, , : An update on aortic causes of ischemic stroke. Curr Opin Neurol 1997; 10: 64–72
- 34, : Cerebrovascular complications of cardiac surgery. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 783–786. San Diego, Calif.: Academic Press, 1997
- 35: Anterior cerebral artery and anterior communicating artery syndromes. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 986–996. Malden, Mass.: Blackwell Science, 1998
- 36, : Middle cerebral artery syndromes. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 997–1027. Malden, Mass.: Blackwell Science, 1998
- 37, : Posterior cerebral artery syndromes. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 1028–1056. Malden, Mass.: Blackwell Science, 1998
- 38, : Lacunes and lacunar syndromes. In Cere-brovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 1090–1102. Malden, Mass.: Blackwell Science, 1998
- 39, , , , : Epidemiological characteristics of lacunar infarcts in a population. Stroke 1991; 22: 1236–1241
- 40: Systemic hypoperfusion brain injury. In Primer on Cere-brovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 289–292. San Diego, Calif.: Academic Press, 1997
- 41, : Clinical features, pathogenesis, and computed tomographic characteristics of internal watershed infarction. Stroke 1993; 24: 1925–1932
- 42, : Frequency and pathogenesis of hemo-dynamic stroke. Stroke 1994; 25: 2179–2182
- 43: Transient ischemic attack—proposal for a new definition. N Engl J Med 2002; 21; 347: 1713–1716
- 44, , : Transient ischemic attacks. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 941–960. Mal-den, Mass.: Blackwell Science, 1998
- 45Ad Hoc Committee on Cerebrovascular Diseases: Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular diseases III. Stroke 1990; 21: 637–676
- 46, , , , : Incidence of transient ischemic attack in Rochester, Minnesota, 1985-1989. Stroke 1998; 29: 2109–2113
- 47, , , : Short-term prognosis after emergency department diagnosis of TIA. J Am Med Assoc 2000; 284: 2901–2906
- 48, , , , , : Ultrasonographic correlates of carotid atherosclerosis in transient ischemic attack and stroke. Stroke 1995; 26: 614–619
- 49, : Markers of subclinical vascular disease and stroke. In The Prevention of Stroke (Eds. GorelickPB, AlterM), p. 105–114. New York, N.Y.: Parthenon Publishing Group, 2002
- 50: Atherosclerotic lesions. Natural history, risk factors, and topography. Arch Pathol Lab Med 1992; 116: 1268–1275
- 51, , : Atherosclerosis, pathogenesis and pathophysiology. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 1308–1318. Malden, Mass.: Blackwell Science, 1998
- 52: The effects of angiotensin-converting enzyme inhibition on endothelial dysfunction: Potential role in myocardial ischemia. Am J Cardiol 1998; 9 (suppl 2): 23S–27S
- 53: Antithrombotic therapy after myocardial infarction. N Engl J Med 2002; 347: 1019–1022
- 54, : Pathophysiologic mechanisms in cerebral blood vessels. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 333–342. Malden, Mass.: Blackwell Science, 1998
- 55: Hypertension. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 142–144. San Diego, Calif.: Academic Press, 1997: 142–144
- 56, , , , , , , : Hypertension associated with reduced plasma thrombomodulin levels and a hypercoagulable state in rats. Clin Exp Hypertens 2003; 25: 73–84
- 57
- 58: Inflammation, infection and homocysteine in atherosclerosis. In The Prevention of Stroke (Eds. GorelickPB, AlterM), p. 49–64. New York, N.Y.: Parthenon Publishing Group, 2002
- 59, , , , , , , : Circulating adhesion molecules in humans: Role of hyperglycemia and hyperinsulinemia. Circulation 2000; 101: 2247–2251
- 60, , , : Human atherosclerosis: I. Cell constituents and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol 1984; 114: 79–93
- 61, , , , , , , , : Minimally modified low-density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci USA 1990; 87: 5134–5138
- 62, , , : Oxidatively modified low-density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987; 84: 2995–2998
- 63, , : Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low-density lipoprotein. Proc Natl Acad Sci USA 1985; 82: 5949–5953
- 64, , , , : Oxidized LDL impairs endothelium-dependent arterial relaxation. Circulation 1989; 80 (suppl II): II-279
- 65, , , , , , , : The protective effect of moderate alcohol consumption on ischemic stroke. J Am Med Assoc 1999; 281: 53–60
- 66, , , , , , , , , , , , , , , , : Prevention of a first stroke: A review of guidelines and a multidisciplinary consensus statement from the National Stroke Association. J Am Med Assoc 1999; 281: 1112–1120
- 67: Risk factors, outcomes, and stroke subtypes for ischemic stroke. Neurology 1997; 49 (suppl 4): S39–S44
- 68: Cigarettes, alcohol, and stroke. N Engl J Med 1986; 315: 1087–1089
- 69: Stroke prevention therapy beyond antithrombotics: Unifying mechanisms in ischemic stroke pathogenesis and implications for therapy. An invited review. Stroke 2002; 33: 862–875
- 70, , , , , , : Hyperhomocyst(e)inemia induces multiorgan damage. Heart Vessels 2000; 15: 135–143
- 71, : Coagulopathies and stroke. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 399–401. San Diego, Calif: Academic Press, 1997
- 72, : Primary platelet disorders. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 401–405. San Diego, Calif: Academic Press, 1997
- 73, , , , , , , , , , , , , , : Antiphospholipid antibodies and stroke in young women. Stroke 2002; 33: 2396–2400
- 74, , , , , , : β2-glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: The Honolulu Heart Program. Stroke 2001; 32: 1701–1706
- 75, , : Overview of bioenergetic failure and metabolic cascades in brain ischemia. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 3–13. Malden, Mass.: Blackwell Science, 1998
- 76: Capillary plugging by granulocytes and no reflow phenomenon in the microcirculation. Federation Proc 1987; 46: 2397–2401
- 77: Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 1994; 6: 47–96
- 78, , : Cytokines, inflammation, and brain injury: Role of tumor necrosis factor. Cerebrovasc Brain Metab Rev 1994; 6: 341–360
- 79: Inflammatory reactions at the blood-endothelial interface in acute stroke. In Advances in Neurology (Eds. SiesjoB, WielochT), p. 281–296. New York: Raven Press, 1996
- 80: Alterations in cerebral endothelial cell function in ischemia. In Advances in Neurology (Eds. SiesjoB, WielochT), p. 301–313. New York: Raven Press, 1996
- 81, , , , , : Acidosis-related brain damage. In Progress in Brain Research (Eds. KogureK, HossmannK-A, SiesjoBK), p. 23–48. Amsterdam, Netherlands: Elsevier Science, 1993
- 82
- 83: Thresholds of ischemic injury. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 193–204. Malden, Mass.: Black-well Science, 1998
- 84: The central role of calcium ions and calcium-permeable channels in ischemic brain injury. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 371–390. Malden, Mass.: Blackwell Science, 1998
- 85, : Blood-brain barrier dysfunction in cerebral ischemia. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 358–370. Malden, Mass.: Blackwell Science, 1998
- 86: Glutamate neurotoxicity and disease of the nervous system. Neuron 1988; 1: 623–634
- 87, : Excitotoxicity and the NMDA receptor—still lethal after eight years. Trends Neurosci 1987; 10: 299–302
- 88: Ischemic energy failure. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 217–226. Malden, Mass.: Blackwell Science, 1998
- 89, , : The ischemic penumbra. In Cerebrovascular Disease: Pathophysiology, Diagnosis, and Management (Eds. GinsbergM, BogousslavskyJ), p. 276–286. Malden, Mass.: Blackwell Science, 1998
- 90, , , , : DC-potential and energy metabolites in focal ischemia. J Cereb Blood Flow Metab 1993; 13 (suppl 1): S450
- 91, , , : Diffusion nuclear magnetic resonance imaging in experimental stroke: Correlation with cerebral metabolites. Stroke 1994; 25: 494–500
- 92, , , , , , : Evolution of acute focal cerebral ischemia in rats observed by localised 1H-MRS, diffusion-weighted MRI, and electrophysiological monitoring. NMR Biomed 1995; 8: 206–214
- 93, , , , : Transient cell depolarization after permanent middle cerebral artery occlusion: An observation by diffusion-weighted MRI and localized 1H-MRS. Magn Reson Med 1994; 31: 337–341
- 94, , , , , , : Progressive derangement of peri-infarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 1992; 12: 193–203
- 95, , , , , : Noninvasive measurement of blood flow, oxygen consumption, and glucose utilization in the same brain regions in man by positron emission tomography: Concise communication. J Nucl Med 1982; 23: 391–399
- 96, , , : Non-invasive regional study of chronic cerebrovascular disorders using the oxygen-15 inhalation technique. J Neurol Neurosurg Psychiatry 1978; 41: 11–17
- 97: Pathophysiology of human cerebral ischemia: studies with positron tomography and 15oxygen. In Brain Imaging and Brain Function (Ed. SokoloffL), p. 139–161. New York: Raven Press, 1985
- 98, , , , , , , : Measurement of local blood flow and oxygen consumption in evolving irreversible cerebral infarction: An in vivo study in man. In Cerebral Vascular Disease, 4th ed. (Eds. MeyerJS, LechnerH, ReivichM, OttEO), p. 205–212. Princeton, N.J.: Excerpta Medica, 1983
- 99, , , , , , , , : Tissue at risk of infarction rescued by early reperfusion: A positron emission tomography study in systemic recombinant tissue plasminogen activator throm-bolysis of acute stroke. J Cereb Blood Flow Metab 1998; 18: 1298–1307
- 100, , , , , , : Early [11C] flumazenil/H2O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke 2000; 31: 366–369
- 101, : Imaging techniques for focal ischemic damage. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 136–141. San Diego, Calif.: Academic Press, 1997
- 102: Measurements of microcirculatory events in the brain in vivo. In Primer on Cerebrovascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 133–136. San Diego, Calif.: Academic Press, 1997
- 103National Stroke Association: Stroke Statistics. Available at www.stroke.org/brain_stat.cfm. Accessed February 24, 2003.
- 104: Ischemic stroke. In Handbook of Neuroepidemiology (Eds. GorelickPB, AlterMA), p. 77–119. New York: Marcel Dekker, 1994
- 105, , , , , : Survival and recurrence after first cerebral infarction: A population-based study in Rochester, Minnesota, 1975 through 1989. Neurology 1998; 50: 208–216
- 106, , , , : Anti-thrombotic and thrombolytic therapy for ischemic stroke. Chest 2001; 119: 300S–320S
- 107, , , , , : European Stroke Prevention Study 2: Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996; 143: 1–13
- 108
- 109Ticlopidine Aspirin Stroke Study Group: Ticlopidine versus aspirin for stroke prevention: On-treatment results from the ticlopidine aspirin stroke study. J Stroke Cerebrovasc Dis 1993; 3: 169–176
- 110, Yusuf S, CURE Study Investigators: The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme: Rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. Eur Heart J 2000; 21: 2033–2041
- 111
- 112, , , , : Supplement to the guidelines for the management of transient ischemic attacks. A statement from the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks, Stroke Council, American Heart Association. Stroke 1999; 30: 2502–2511
- 113, , , , , : Thrombotic thrombocytopenic purpura associated with ticlopidine: A review of 60 cases. Ann Intern Med 1998; 128: 541–544
- 114, , , , , , , , , , , , for the ASA and Carotid Endarterectomy (ACE) Trial Colloborators: Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: A randomised controlled trial. Lancet 1999; 353: 2179–2184
- 115: Dipyridamole. In Platelets (Ed. MichelsonAD), p. 803–815. San Diego, Calif.: Academic Press, 2002
- 116
- 117, , , : Dipyridamole decreases platelet-derived growth factor levels in human serum. Arteriosclerosis 1987; 7: 152–155
- 118The ESPS Group: The European Stroke Prevention Study (ESPS): Principal end-points. Lancet 1987; 2: 1351–1354
- 119, : Reversing endothelial dysfunction with ACE inhibitors. Circulation 1996; 94: 240–243
- 120Heart Outcomes Prevention Evaluation (HOPE) Study Investigators: Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the HOPE study and MICRO-HOPE substudy. Lancet 2000; 355: 253–259
- 121ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group: Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium-channel blocker vs. diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALL-HAT). J Am Med Assoc 2002; 288: 2981–2997
- 122, , : New evidence for stroke prevention. J Am Med Assoc 2002; 288: 1388–1398
- 123, , , , , , , , , , , for the Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group: Effects of lovastatin on early carotid atherosclerosis and cardiovascular events. Circulation 1994; 90: 1679–1687
- 124, , , , , , , , : Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: A randomized, controlled clinical trial. Ann Intern Med 1996; 124: 548–556
- 125, , , , , , , , : HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human en-dothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23: 58–63
- 126, , , , , , , , , : Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation. A new drug-drug interaction. Circulation 2003; 107: 32–37
- 127, , , , , , , , , , for the Veterans Affairs Cooperative Studies Program 309 Trialist Group: Carotid endarterectomy and prevention of cerebral ischemia in symptomatic carotid stenosis. J Am Med Assoc 1991; 266: 3289–3294
- 128
- 129, , , , : Carotid artery stenting: Technical considerations. Am J Neuroradiol 2002; 21: 1736–1743
- 130, , , , , , : Elective stenting of symptomatic basilar artery stenosis. Stroke 2000; 31: 95–99
- 131, , , , : Short-term arterio-graphic and clinical outcome after cerebral angioplasty and stenting for intracranial vertebrobasilar and carotid atherosclerotic occlusive disease. Am J Neuroradiol 2000; 21: 249–254
- 132: Anticoagulation for stroke prevention. In The Prevention of Stroke (Eds. GorelickPB, AlterM), p. 208–221. New York, N.Y.: Parthenon Publishing, 2002
- 133, : Status of patent foramen ovale, atrial septal aneurysm, atrial septal defect and aortic arch atheroma as risk factors for stroke. Neuroepidemiology 1997; 16: 217–223
- 134, , , , Mohr JP, PFO in Cryptogenic Stroke Study (PICSS) Investigators: Effect of medical treatment in stroke patients with patent foramen ovale: Patent foramen ovale in Cryptogenic Stroke Study. Circulation 2002; 105: 2625–2631
- 135: Emerging treatments for stroke. In Primer on Cerebro-vascular Diseases (Eds. WelchKMA, CaplanLR, ReisDJ, SiesjoBK, WeirB), p. 791–793. San Diego, Calif.: Academic Press, 1997
- 136, , , , , : Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke (STARS) study. J Am Med Assoc 2000; 283: 1145–1150
- 137, , , , , , , : Early intravenous throm-bolysis for acute ischemic stroke in a community-based approach. Stroke 1998; 29: 1544–1549
- 138, , : The Canadian Activase for Stroke Effectiveness Study (CASES): Final results (abstr). Cere-brovasc Dis 2002; 13 (suppl 3): 99
- 139, , , , : Treating acute stroke patients with intravenous tPA. The OSF stroke network experience. Stroke 2000; 31: 77–81
- 140, , , , , , , , , , , , for the PROACT (Prolyse in Acute Cerebral Thromboembolism) Investigators: Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. J Am Med Assoc 1999; 282: 2003–2011
- 141, , , , , , , , , , , , for the Warfarin-Aspirin Recurrent Stroke Study Group: A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med 2001; 345: 1444–1451

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